Tuesday 14 April 2009

Preventing and reversing hair loss

At the moment, there’s unfortunately no cure for womens hair loss! You can use a variety of treatments, but none of them guarantees success.
Many companies dealing with hair loss promise you a definite cure. Various hair integration and hair volumising companies also sell products supposedly curing hair loss, and claim their systems will contribute to it as well. We can assure you - they are not telling you the truth! And if you’d like more information, please check the U.S. based site http://www.hairlossscams.com/.

Below, you'll find a list of treatments that can contribute to improving a case of hair loss but, once again: none of them is a cure for baldness.
Propecia
Merck Pharmaceuticals sought to find the smallest effective quantity of finasteride and to test its long-term effects on men aged between 18 and 41 with mild-to-moderate thinning hair. Based on their research, 1mg daily was selected and, after 2 years of daily treatment, some of the male patients have regrown parts of their hair.

Minoxidil

Minoxidil was first used in tablet form as a medicine to treat high blood pressure, but it was noticed that some patients being treated with Minoxidil experienced excessive hair growth (hypertrichosis) as a side effect. Further research showed that by applying Minoxidil in solution form directly to the scalp, it could prove to be beneficial to those experiencing topical hair loss.
In controlled clinical studies of women aged 18-45, some women with moderate degrees of hereditary hair loss reported re-growth after using 2% minoxidil. Initial results occur at 4 months with maximum results occurring at 8 months.

Low-level laser therapy

A low level laser is shone directly on the scalp to stimulate hair growth through "Photo-Biostimulation" of the hair follicles. One product of these low-level laser therapies is the "Hairmax Lasercomb". There is no peer-reviewed evidence to support this claim. The Lasercomb is FDA approved only with regard to safety. The Leimo laser was recently approved by the TGA (Therapeutic Goods Administration) of Australia as a Class IIa Medical Device that regrows hair. Its ARTG number is 139 456.

Surgery

Surgery is another method of reversing hair loss and baldness, although it may be considered somewhat extreme. The surgical methods used include hair transplantation, whereby hair-producing follicles are taken from the back and sides of the head and injected into bald or thinning areas.

Hair Multiplication

Looking forward: one prospective treatment currently in development is that of hair multiplication/hair cloning. And it has been shown to work on mice!
It involves extracting self-replenishing follicle stem cells, multiplying them many times over in the lab, and microinjecting them into the scalp. It is expected by some scientists to be available to the public in 2009–2015. Subsequent versions of the treatment are expected by some scientists to be able to cause these follicle stem cells to simply signal the surrounding hair follicles to rejuvenate.

In October 2006, UK biotechnology firm, Intercytex, announced they had successfully tested a method of removing hair follicles from the back of the neck, multiplying them and then reimplanting the cells into the scalp (Hair multiplication). The initial testing resulted in 70% of male patients regrowing hair. This treatment method is expected to be available to the public by 2009.

In January 2007, Italian stem-cell researchers announced that tghey had developed a new technique for curing baldness. Pierluigi Santi of a Genoa clinic said stem cells could be used to "multiply" hair roots. He said the clinic would be ready to perform its first hair transplants on priority patients - those who have lost their hair in fires or other accidents - within a few months. “After that” he said "we'll open our doors to paying customers". Santi's approach works by splitting roots and growing new follicles.
Ketoconazole
Topical application of ketoconazole, which is both an anti-fungal and a potent 5-alpha reductase inhibitor, is often used as a supplement to other approaches.
Unsaturated Fatty Acids
Particular unsaturated fatty acids such as gamma linolenic acid are 5 alpha reductase inhibitors if taken internally.

Placebos

Interestingly, placebo treatments in studies often have reasonable success rates, though not as high as the products being tested, and even similar side-effects as the products. For example, in Finasteride (Propecia) studies, the percent of patients with any drug-related sexual adverse experience was 3.8% compared with 2.0% in the placebo group.
Exercise

Regular aerobic exercise can help keep androgen levels (particularly free testosterone levels) naturally lower while maintaining overall health, lowering stress and increasing SHBG.
Weight training without aerobic exercise may increase testosterone. One study suggests that both heavy exercise and increased fat intake, in combination, are required for increased free testosterone in strength trainers. Increased total or free testosterone would help them build and repair muscle, but may cause susceptible individuals to lose hair.

However, there is at least one study that indicates a decline in free testosterone combined with an increase in strength due to an (unspecified) strength training regime.

Stress Reduction

Stress reduction can be helpful in slowing hair loss.

Immunosuppressants

Immunosuppressants applied to the scalp have been shown to temporarily reverse alopecia areata, though the side effects of some of these drugs make such therapy questionable.

Saw Palmetto

Saw Palmetto (Serenoa repens) is a herbal DHT inhibitor often claimed to be cheaper and to have fewer side effects than finasteride and dutasteride. Unlike other 5alpha-reductase inhibitors, Serenoa Repens induces its effects without interfering with the cellular capacity to secrete PSA. Saw Palmetto extract has been demonstrated to inhibit both isoforms of 5-alpha-reductase unlike finasteride which only inhibits the (predominant) type 2 isoenzyme of 5-alpha-reductase.

Polygonum Multiflorum

Polygonum Multiflorum is a traditional Chinese cure for hair loss. P. multiflorum contains stilbene glycosides similar to resveratrol.

Beta Sitosterol

Beta Sitosterol, which is a constituent of many seed oils, can help to treat BHP by lowering cholesterol. If used for this purpose, an extract is best. However, consuming large amounts of oil to get at small quantities of Beta Sitosterol is likely to exacerbate male pattern baldness.

Anti-Androgens

While drastic, broad spectrum anti-androgens such as flutamide are sometimes used topically. Flutamide is potent enough to have a feminizing effect in men, including growth of the breasts.
Hedgehog Agonists

In March 2006, Curis announced that it had received the first preclinical milestone, a $1,000,000 cash payment, in its hair growth program with Procter & Gamble Pharmaceuticals, a division of The Procter & Gamble Company. The programme is focused on the potential development of a topical Hedgehog agonist for hair growth disorders, such as male pattern baldness and female hair loss. The Curis hair loss research program was shut down in May 2007 because the process did not meet the proper safety standards.

WNT Gene Related

In May 2007, US company Follica Inc, announced they have licensed technology from the University of Pennsylvania which can regenerate hair follicles by reawakening genes which were once active only in the embryo stage of human development.

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